In this study, the HYbrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) model is used to simulate the deposition of PM2.5 aerosol particles emitted by biomass fires in the Baoulé loop, from the locality of Neguela in Mali. This simulation is done through the calculation and the analysis of backward trajectories maps in height configuration for the attribution of the sources as well as the deposition maps. The sources are located along the backward trajectoires. The activities of biomass fires in the zone are observed mainly in the dry season with maximum frequency at the end of the dry season and early wintering. This period is also a period of dry deposition of PM2.5 particles. The end of the dry season and early wintering is the period of burning of growing spaces. This practice has a positive aspect in the case of a supply of phosphate, nitrogenous and potash nutrients. At the end of the dry season, the backward trajectoires show the origin of the particles emitted by the bush fires of Guinea, the Ivory Coast and the surroundings of Néguéla. In dry seasons, dust storms bring PM2.5 particles from the North. In winter, air masses are transported south and south-west from the Atlantic Ocean. This promotes precipitation, which in turn results in the wet deposition of PM2.5 particles that are removed from the atmosphere. During the rainy season, there is no major emission of particles except those of domestic combustion. Deposition calculations by HYSPLIT model are in good agreement with in situ measurements