Influence of Superoxide Dismutase Activity on Diabetic Neuropathy Patients

Diabetic neuropathy (DN) is one of the most common troublesome microvascular complications and it has also got some oxidative stress mechanism associated with nerve damage, followed by structural and functional change. The present study aimed in assessing the antioxidant superoxide dismutase activity in type 2 diabetes patients with neuropathy. The study was conducted with 109 diabetic neuropathy patients from the out patients endocrinology department of Ramakrishna Mission Seva Pratishthan, Kolkata. 30 healthy controls were also taken in this study. All the procedures were done with the consent of the participants. After confirmed positive sensory / polyneuropathy problem by nerve conduction velocity (NCV) test, the patients have been selected in this study. The present result shows that SOD activity in DN was much higher than that of control group. Furthermore, a considerable difference was observed in male and female patients when different duration of the disease was considered.