The full 9 stepped cycle of proton conductance and antispiral - like evolutionary back steps from second late evolution time equation to first early evolution time equation during some pathology

The reaction medium of “Donators + membrane - redox potentials three - state line system + O2 + АDP + Pi + H+ + nH + membrane space = (ATP + heat energy) + H2O + nH + matrix + CO2” are the places, where have been occurred the following four more important processes as : • Maintaining of clockwise normal flow of electrons and protons with duration of 4-5 second of every cycle • Temporarily stop of clockwise normal flow of electrons and protons • Complete stop of clockwise normal flow of electrons and protons • Antispiral-like evolutionary back steps from second evolution late time equation of flow of electrons and protons to early evolution first time equation with provocation of pathological process as cancer. According to philosophical principle, all biological process in our planet during last 4 billion years had been developed by the spiral – like evolution steps by transition from simple regulation to more complex regulation as from glycolysis related ATP synthesis, based in the flow of electrons and protons without participation of membrane - redox potentials three - state line system and oxygen to Krebs cycle, proton gradient related ATP synthesis, based in the flow of electrons and protons with oxygen participation using membrane - redox potentials three - state line system. But the notion relating to antispiral-like evolutionary back steps from second late evolution time equation to early evolution time first equation of flow of electrons and protons with provocation of cancer process have been connected with the transition of regulations from more complex regulation to simple regulation based equation as from Krebs cycle dependent, proton gradient based ATP synthesis functioned owing to the flow of electrons and protons with oxygen participation, using membrane - redox potentials three - state line system to early form of glycolysis related ATP synthesis, based in the flow of electrons and protons without participation of membrane - redox potentials three - state line system and oxygen. Temporarily stop of clockwise normal flow of electrons and protons with duration of 4 - 5 second of every cycle means that under influence of many pathological factors have been caused the partial blockage of electron and proton conductance within the full 9 stepped cycle of proton conductance inside human body proposed by M.Ambaga, which have included such well known metabolic pathways as glycolysis, Krebs cycle, betta oxidation of fatty acids, aminoacid oxidation.