ffect of withani a somnifera (Ashwagandha) in obsessive compulsive disorder on albino rats

Background: Albino rats have natural tendency of burying behavior, more when they are under stress, this provides an useful model for study of Obsessive Compulsive Disorders. Aim and Objectives: 1. To observe effectiveness of Withania Somnifera in Obsessive compulsive disorder. 2. To observe effect of Withania Somnifera in Obsessive Compulsive Disorder on Albino rats. 3. To evaluate appropriate dosage of WithaniaSomnifera for Obsessive Compulsive Disorder. Methods: Rats are divided into six groups, the control group was given normal saline and other groups received Withania Somnifera (Ashwagandha) in increasing doses. The rats were placed in a box with marbles in each and the burying behavior is obsereved. Results: It was obserevedthat, the increasing dosage of Withania Somnifera less marbles are buried by rats. In control group 15 out of 18 marbles are found buried on an average, with 50mg/kg 12 marbles on an average are buried, with 100 mg/kg 8 marbles are found to be buried and with 200 mg/kg only 5 marbles are buried after one hour. Conclusion: Withania Somnifera (Ashwagandha) is effective in treating Obsessive Compulsive Disorders in Rats.