Introduction: Through and through bony lesions are characterized by erosion of both buccal and palatal/lingual bony plate in relations to the teeth apices. PRP has been used in various fields and proven beneficial in healing. Case description: Lack of both buccal and lingual cortical plates was confirmed both clinically and CBCT in the case. Endodontic Microsurgery was performed following modern techniques and the lesions were filled with PRP before closure. A follow up was done at 12 month follow up. Discussion: Various studies have demonstrated the role of different GTR techniques in the healing of through and through lesions. PRP being a rich source of growth factors found to enhance healing. However there is a scarce literature on the use of PRP in endodontics. We have assessed the radiographic healing with the use of PRP. Conclusion: Our case report has demonstrated both clinical and radiographic success using PRP in through and through defect at the end of 12 months.