The role of clomiphene citrate (clomid) challenge test and letrozole (femara) challenge test in assessment of ovarian reserve in infertile patients

The aim of our research is to study the OR in infertile patients by assessing hormonal status including basal FSH, LH, ovarian volume ,ovarian diameter, no. of small antral follicle, endometrial thickness, CCCT and femara challenge test. It was carried in the fertility center of Al-Saddar teaching hospital of Al-Najaf city from January 2009 to August 2009. A comparison was done between three groups: Control group (25 patients) without treatment. CCCT group (25 patients) with induction of ovulation by clomiphene citrate tab. And lastly femara challenge test group treated by letrozole tab. In day 2 of MC history was taken about age, cause of infertility, type of infertility, and duration of it. After history, measurement of hormonal level of FSH, LH and TVUS done to all patients and measured ovarian diameter, ovarian volume, endometrial thickness and no. of small antral follicle. In day 10 of MC all these measurement repeated, divided our studied groups into 2 groups according to FSH level (< 12mIu/ml regarded as normal FSH groups and >12 mIu/ml regarded as abnormal FSH groups) and study the effectiveness of CCCT and femara challenge tests in assessing OR by measurement of ovarian volume, ovarian diameter, no. of antral follicle and endometrial thickness. We conclude that CCCT and femara challenge tests had better predictive value than measurement of basal FSH day 2 in assessment of OR.