A clinician should have complete knowledge about anatomic variations of macrostructure and the external as well as internal anatomy of the tooth which is essential for a successful outcome. An awareness and thorough knowledge of root canal morphology contribute to the success of root canal treatment. Successful endodontic treatment includes the acts of locating the root canal orifice, chemo-mechanical cleaning, and shaping the root canal system before placement of a dense root canal filling with a fluid-tight seal. Anomalies in the tooth are often encountered which poses difficulties in dental treatments. As in any other teeth, mandibular molars are also prone to anatomic variation. Morphologic variations in mandibular first molars are seen in the number of root canals or the number of roots. An additional third root, first mentioned in the literature by Carabelli, is termed as Radix Entomolaris (RE). This supernumerary root is located distolingually in mandibular molars, mainly first molars. An additional root at the mesiobuccally side is termed as Radix Paramolaris (RP). This case series focuses mainly on the diagnosis and management of variable root canal anatomies like radix entomolaris and paramolaris in mandibular molars.