An Adrenal Ganglioneuroma (AGN) is an extremely rare, hormonally silent benign tumor. It is common for AGNs to be erroneously diagnosed, considered as other adrenal malignancies. Therefore it is imperative that, in work-up of adrenal incidentalomas, other less common aetiologies such as ganglioneuroma should be considered, and the latter should be suspected in adrenal mass on imaging without associated hormone hyper production. Here, the present authors report a case of giant adrenal ganglioneuroma in a 25-year-old female presenting with vague right side abdominal pain, after abdominal computed tomography (CT) scanning, the patient underwent an open right adrenalectomy and histopathological examination further confirmed the lesion as giant AGN, which measured 16 cm * 13 cm* 10 cm.