Background: Despite known complications and a high recurrence rate, the standard treatment of pilonidal disease still consists of surgical excision of the sinusoidal cyst with primary wound closure. We were the first in Middle East to introduce a new treatment technique using SETON with a radial laser probe (Sinus Laser-Assisted Closure, SILACTM, Biolitec, Germany). Aim of the study: To assess the efficacy of laser (diode) SETON_SILAC as a therapy to the pilonidal sinus. Methods: A prospective study conducted in Hemocure Surgery Department, EL-Rahma Hospital and included 100 patient were operated with the SETON_SILAC technique by two surgeons from June 2018 to December 2019. Results: The median follow up duration was 1 year. The initial success rate was 96% (96/100).There were no complications during or after surgery. Mean patient satisfaction was 9.0 (3.0 to 10.0).Thirteen percent of patients did not require any analgesia, 37% used only when needed, of which 32% for less than one week and 10% for one to two weeks. Conclusion: SETON SILAC is a quick, safe and minimally invasive technique for destruction of the pilonidal cyst and sinus. Success rate and patient satisfaction are high, making this new therapy an attractive option for the majority of the patients with pilonidal disease. Long term results have to be awaited.