Trividha Satva and Dhatu Sarata are two main concepts on which a person’s healthy status depends. In different major texts of Ayurveda there is so much description found on Trividha Satva and Dhatu Sara. Sixteen Prakriti are mentioned on the basis of Manasika Guna predominance and eight Dhatu Sara are described depending on the specific and pure qualities of a particular Dhatu. Trividha Satva are responsible for healthy conduction of body and maintaining the quality of life of an individual and Dhatu Sarata also helps in providing strength against the disease. So there is needed to make an effort to find out the relation between Trividha Satva and Dhatu Sara and to conclude it with probable logics and concepts.