Vaccination is induction of immunity by injecting a dead or attenuated form of a pathogen. Periodontal diseases are one such group of infectious bacterial diseases, against which vaccine research is still going on. The complexities in the etiopathogenesis of the periodontal diseases have been the prime obstacle in the hunt for vaccine. The availability of periodontal vaccine would not only prevent or modulate the course of periodontal diseases, but also enhance the quality of life of people for whom periodontal treatment cannot be easily obtained.