Aim: This study aimed to assesspatient acceptance & trust for DTC telemedicine for outpatient services at King Abdullah Medical City, Makkah. Method: The researcher adopted the descriptive analysis cross-sectional design. The population of the study was the number of scheduled outpatients in King Abdullah Medical City- outpatient clinics, Makkah city, Saudi Arabia during 2021. To collect the needed data, the questionnaire is used as a tool for collecting data. The response rate was 100%. Data were analyzed by using SPSS. Two hypotheses were tested based on data collected. Result: The results of the Chi square analysis revealeda significant relation between telemedicine services and both patients trust and acceptance of direct to consumer telemedicine (P value <0.0001). Conclusion and recommendation: Telemedicine was proved to be a valuable addition to usual care. Patients were generally showed a great trust and acceptance in telemedicine service implemented. The recommendations made from this study are the following: • the healthcare organization should increase telemedicine services with taking care of quantity as well as quality. And focus on providing the healthcare workers with the appropriate information and training about telemedicine.