
The Temporomandibular joint (TMJ) Hypermobility is very unpleasant and distressing condition, which causes hypertranslation of the mandibular condyle anterior and superior to the articular eminence during mouth opening. It can be classified according to its reduction as subluxation or dislocation. In recent times, various treatment modalities are available for its management. Surgery is considered as a last resort for TMJ Hypermobilty but recent recognition of its failures has developed the interest and research in ‘Prolotherapy’ (PrT). PrT has been used for treating ligamentous laxity and related musculoskeletal conditions. Objective: This study was conducted on a 25 years old male patient to check whether the PrT therapy is effective in treating the TMJ hypermobility. Method: 1 ml solution of 25% Dextrose was injected around the Left TMJ area for 2 sessions at a interval of 2 week and patient was recalled for regular follow-up. Results: The patient was evaluated at each follow-up for subjective symptoms like mouth opening, frequency of locking episode, Visual Analogue Scale for Quality of life and pain on function, chewing efficiency and for clicking sound, on follow–up it was found that the subjective symptoms improved within short period of time. Conclusion: The results of this case report show that PrT can be used as an efficient, simple, and conservative method to treat TMJ Hypermobility.