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Non-cholesterol-dependent biological effects of statins: a new horizon in periodontal therapy

Author:

Rakesh Kumar Medhi, Nischal Das and Swarga Jyoti Das

Subject Area:

Health Sciences

Abstract:

Periodontitis is an inflammatory process causing destruction of the periodontal tissues and alveolar bone. Various adjunctive treatment approaches are introduced along with scaling and root planing for treating periodontitis; Statins being one of them. Statins are considered as “Gold-standard” to treat hyperlipidemia and widely used to control cardiovascular and cerebrovascular diseases. Apart from the lipid-lowering properties, various non-cholesterol-dependent biological effects of statins are captivated. These include Antioxidative, Antibacterial, Antithrombotic, Anti-inflammatory, Immunomodulatory, and Osteomodulatory properties. Considering these effects, this group of drugs might play a potential role in regenerative periodontal therapy.

PDF file:

41322.pdf

DOI: https://doi.org/10.24941/ijcr.41322.05.2021

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