Low molecular weight components of colostrum regulate the activity of cellular component of the immune system in animals with cu-induced liver fibrosis

It has been study the effect of low molecular weight components of colostrum (LMCC) on some parameters of immune system and prooxidant-antioxidant system on the model of Cu-induced liver fibrosis. For the induction of liver fibrosis in rats were injected copper sulphate intraperitoneally three times successively at a dose 33% of lethal in rats. It is shown that the most marked changes in the initial stages of development of fibrosis manifested at the level of pro-antioxidant system, which is correlated with a change in the pattern of immunological parameters. These changes are manifested in the inhibition the growth of animals and decreasing their body temperature.Administration LMCC animals with liver fibrosis was accompanied by "removing" oxidative stress, activating of cellular immunity and restoring the growth rate and body temperature of the experimental animals.