Leukoplakia- a comprehensive clinico-pathological review

Leukoplakia, one of the most common potentially malignant disorder of the oral mucosa, usually presents whitish patch over the oral mucosa. The term ‘Leukoplakia’ is a clinical term only, when biopsy is taken the term leukoplakia should be replaced by the diagnosis obtained histopathologically. The malignant transformation rate varies in different parts of the world, as a result of differences in tobacco & dietary habit and genetic mutations. The management of oral leukoplakia depends on their types, varies from “wait and see” attitude and topical chemopreventive agents to complete surgical removal. In this article, we have reviewed the literature to provide comprehensive update on leukoplakia.