Vacuum-assisted closure (VAC) therapy is a new modality in wound care after growth factors and hydrocolloid dressing, in the treatment of large infected wounds. We have been using this technique for diabetic foot ulcers. A 58yr old diabetic man who is a post CABG pt, presented with a large horse shoe shaped peri anal abscess after drainage of the abscess in the O.R., a diversion colostomy was done and VAC therapy was applied, a complete closure of the peri anal wound by secondary suturing was achieved in 6 weeks. Avoiding regular dressing and constant soiling of the wound, which is a hindrance in the management of large infected wounds.