Educational inputs are resources invested in the school system with an aim of enhancing quality of education. In Kenya quality secondary education is measured primarily by performance in examination, access; and availability, adequacy and utilization of resources. In Kenya there are differences in the quality of education provided by schools as some schools perform better than others. The overall mean score in Kenya Certificate of Secondary Education Examination between 2011 to 2017 in Migori County was 4.530. The national mean score in Kenya Certificate of Secondary school Education examination from 2011 to 2017 was 4.617. The objective of this study was to establish the influence of teacher characteristics on quality of secondary school education in Migori County, Kenya. The study established that teacher characteristics accounted for 71.4% of the variation in the quality of secondary school education in Migori County as signified by Adjusted R square of 0.714. This means that teacher characteristics had a strong positive influence on the quality of secondary school education. The study concluded that teacher characteristics play a key role in enhancing the quality of secondary school education.