In Toamasina, our study emphasizes that addiction was really a mask of depression which is in high level in 71% of alcoholic-addicted, in 63% of cannabis-addicted, in 34% of tobacco-addicted and in 78% of people addicted in illicit psychotrop drugs. Even if it was the contrary in some studies on literacy, as far as our studies was concerned, in order to improve taking care of drug-addicted people in Toamasina, and it seems also available to cases the other Malagasy areas, we should even recommend to detect systematically depression mood in them, and if it is the case, it should be treated at the same time as the desintoxication cure properly, in order to prevent committing suicide. According to the epidemio-clinical profile of this association of addiction and depression mood in Toamasina, and also because of their multifactor etiologies, its treatment should need then multidisciplinary concertation (Psychiatrist, General physicians, Psychotherapist, social workers).