Formulation and evaluation of oxiconazole emulgel for topical drug delivery

Emulgel is one of the emerging topical drug delivery system for the delivery of hydrophobic drugs which overcome various disadvantages of ointments and creams such as greasiness and phase inversion. The aim of present work was to develop and evaluate Oxiconazole emulgel with controlled release. The oxiconazole used in treatment of various fungal infections such as cutaneous and subcutaneous diseases like acne and psoriasis. Different formulations (F1-F4) of Oxiconazole emulgel was prepared by using carbopol 934 as gelling agent with varying concentrations of oily phase such as liquid paraffin and Tween-80 and Span-80 as a emulsifying agent. The prepared emulgels were evaluated for physical appearance, pH, drug content, In-vitro diffusion studies, microbiological assay and skin irritation test. By the In-vitro diffusion studies it was observed that formulation F1 showed 47.2% and marketed formulation (Oxistat cream) showed 42.1% of drug release after 10 hours and results concluded that the formulation F1 showed better releasing of drug than comparison with marketed cream.