Patient’s primary concern before starting orthodontic treatment is how long treatment will proceed. Long orthodontic treatment time poses several disadvantages like a higher predisposition to dental caries, gingival recession and root resorption. Accelerating orthodontic tooth movement can notably reduce treatment duration and risks of side effects. Plenty of methods are available to accelerate tooth movement, such as surgical methods (corticotomy, piezosurgery etc.), mechanical/physical stimulation methods (vibration, lasers), drugs, etc. These methods have successfully proven to reduce treatment times by up to 70%.This review encapsulates the current knowledge on the molecular mechanisms underlying accelerated orthodontic tooth movement, and the clinical and experimental methods that accelerate orthodontic tooth movement.