This study’s objective is to assess the performance of the Second National Tobacco Control Strategy 2559-2562 B.E. (2016-2019) vis-à-vis the target set. This research was a combined method evaluation research by collecting both quantitative and qualitative data from October to December 2562 B.E. (2019). The studied population in group 1 was the Thai population aged 15 years and over. A total of 6,660 people and group 2 were youths who were 15-19 years old. A total of 6,965 subjects were recruited using the stratified two-stage cluster sampling method in the provinces with the median of the highest and lowest smoking rates. The past 3 years of the 12 health districts and 25 Bangkok provinces. The results showed that the prevalence of tobacco use among the Thai population aged 15 years and over was 16.3% (95% CI: 14.2, 18.5) with the prevalence value adjusted according to the Age Standard Structure (ASR) accounted for 16.1 percent which can be reduced according to the target (not more than 16.7%). Males have 11.6 times higher smoking rates than females (29.0% and 2.5%, respectively) and the protection of public health from the dangers of tobacco smoke the prevalence of seeing smokers / using tobacco products or having been exposed to secondhand smoke in public places is required by law to be 100% non-smoking in five places: markets, public bus stations, religious institutions, lower level higher education, and public health facilities. They were equal to 20.1%, 16.3%, 7.2%, 6.5% and 4.8%, respectively which decreased more than the target set. It was concluded that the results of the Second National Tobacco Control Strategy Plan 2559-2562 B.E. (2016-2019) achieved the target designated.