E-learning is witnessing a big pace in education field and has a significant role in higher education due to the rapid and huge development in technology. Smart book is one of these developments that has enriched the educational process and has its influence on students’ performance. This research studies the effect of smart e-book on the pass rate of students in an IT course at the Arab Open University branches in six Middle East countries and investigates and deduces the factors that affect the obtained results.