Rupture Diabetes mellitus (DM) is a heterogeneous disease. One of the chief injuries arising from hypergly¬cemia is injury to vasculature, which is classified as either small vascular injury (microvascular disease) or injury to the large blood vessels of the body (macrovascular disease). Moringa oleifera and Hordeumleporinum methanol extract mixture in Microvascular Complications (nephropathy disease).Models of STZ-induced diabetic nephropathy injected once into the tail vein of grouped Wistar rat with STZ 60mg/kg in sodium citrate buffer (1ml/kg). Biochemical assessment of renal injury by urine albumin excretion is considered to be one of the most sensitive markers of renal injury. Blood sample for estimation of creatinine, blood urea nitrogen, uric acid and total protein. Histopathological examination at the end period and Statistical analysis was performed as the mean± standard deviation (SD). Aims and Objective: To evaluate the effect of Moringa oleifera, Hordeumvulgare and their mixture in Microvascular Complications of Streptozotocin (STZ) induced Diabetes Mellitus Wistar rat.