CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Effect of low-level laser irradiation (llli) on expression of vascular endothelial growth factor (vegf) and inducible nitric oxide synthase (inos) in rats model of myocardial infarction

Author: 
Khan Mohammed Firoj, Hai binYu and Xian en Fa
Subject Area: 
Health Sciences
Abstract: 

Objective: To observe the effect and significance of low-level laser irradiation (LLLI) on expression of vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) in rat model of myocardium infarction (RMMI). Method: 110 SD rats were randomly divided into Sham, control and treatment group. Control and treatment group established rat model of myocardial infarction (RMMI) by ligation of left anterior descending artery while Sham group performed only threading around the same site of ligation. After 3 weeks of RMMI, irradiation was done at infarct region in the treatment group by using low level laser diode (635nm, 6mW, 125s, 0.96J / cm2), while the control group and the sham group were irradiating without putting the power on. 4 to 6 rats were euthanized at 1h, 24h, 48h, 72h and 7d after LLLI. The irradiated myocardial tissue were excised to measure the expression of VEGF and iNOS by using Western blot method. Results: After the LLLI treatment, VEGF expression continued to rise at 1h-48h in the treatment group, peak expression compared with the control group (2.27 ± 0.22:1.46 ± 0.19,P<0.05) there was a statistically significant difference. iNOS expression started to rise after exposure at 1h in the treatment group, peaked at 48h, compared with the control group (1.90 ± 0.18:1.4 ± 0.08,P<0.05) there was a statistically significant difference. 1 week after the 2nd thoracic irradiation, compared control group with the treatment group; left ventricular ejection fraction (LVEF) (%) (39.83 ± 1.64vs47.62 ± 2.75,P<0.05), left ventricular fractional shortening rates (LVFS) (%) (18.03 ± 1.25vs24.15 ± 2.53,P<0.05), there was a statistically significant difference; 1 week after LLLI, a new capillary density compared between the control group and the treatment group (69.50 ±14.50)/mm2 vs. (111.50 ± 9.00)/mm2,P<0.05, there was a statistically significant difference. Conclusion: LLLI can significantly increase expression of VEGF and iNOS in infarcted myocardium which can promote angiogenesis to improve the microcirculation of infarct zone and improve the cardiac function.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran