CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Effect of Aliskiren on renal using UUO mmp-3/timp-2 model

Author: 
Ngueji Kakubu Olivier, Wang Li Min, Tshibadi Kushadi Michel, Wang Shu jing, Wang Wen Juan and Mufuta Ntambwe Simon
Subject Area: 
Health Sciences
Abstract: 

Objective: To investigate the effect of aliskiren by expression of matrix metalloproteinase- 3 (MMP-3); Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) on kidney of rats with unilateral ureteral obstruction (UUO).In addition, to explore its action in the process of renal interstitial Fibrosis. Materials and Methods: 60 male SD rats were randomly divided into sham operation group, model group and treatment group. Model group and treatment group were ligated and the left ureter transection induced the unilateral ureteral obstruction (UUO) model group began treatment after surgery, Aliskiren administered 50mg / kg oral treatment once a day and sham operation group and model group were given the same amount of physiological saline gavage. After 1 week, 2 weeks; 10 rats of each group were sacrificed respectively, left kidney specimens, do Hematoxylin Oesin (HE) and Masson staining, and by immunohistochemically SABC method to detect renal tissue expression of MMP-3, TIMP-2. Results: HE and Masson staining: the degree of tubular damage in treated rats was less than model group (P <0.05). Immunohistochemistry showed that in the UUO rat model of renal tissue, the expression of the treatment group with a time point of MMP-3 was higher than the model group, and the expression of TIMP-2 is lower than the model group (P <0.05). Conclusion: Aliskiren by regulation of the renal tissue MMP-3 / TIMP-2 ratio imbalance may play a renal protective effect in renal interstitial fibrosis process.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran