CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Dissolution characterization of compounded ibuprofen-containing tablet formulations for potentially faster pain relief: the effects of disintegrants

Author: 
Yousif Rojeab, Cal Von Stein, Elaina Gollmar, Jessica Fernandez, Alexandria Dingess, Elaine Chiu, Taylor Hoffman, Deirdre Myers
Subject Area: 
Life Sciences
Abstract: 

Ibuprofen is one of the most commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) to alleviate pain and inflammation. Faster disintegration and consequently dissolution of an ibuprofen-containing oral tablet is expected to speed up relief from pain and/or inflammation. The purpose of this study was to 1) compound series of ibuprofen-containing tablet formulations for oral administration with varied types and amounts of disintegrants and 2) thoroughly evaluate ibuprofen’s dissolution rates and extents from those formulations compared to a commercially available tablet. United States Pharmacopeia (USP) type II dissolution apparatus was implemented in the dissolution studies where samples were collected at predetermined time points and analyzed for ibuprofen content using a validated High Performance Liquid Chromatography (HPLC) method. Statistical analyses of dissolution results were performed based on single-factor ANOVA. Three of the six compounded formulations; ones with starch 5%, starch 20% and microcrystalline cellulose (MCC) 10% as the disintegrants, demonstrated higher rates of dissolution compared to the commercial product (p< 0.0003, 0.0032 and 0.0043, respectively). For dissolution extents, two formulations; ones with MCC 20% and hypromellose 2910 USP (E4M) 5% as the disintegrants, showed enhancement over commercial tablet (p< 0.001 and 0.0103, respectively). These results demonstrate the feasibility of compounding ibuprofen-containing tablets for oral administration with enhanced dissolution characteristics over a commercially available tablet, thereby potentially reducing time to pharmacologic effect. More importantly, our results demonstrate that sound formulation optimization of a compounded tablet formula can be directly guided by in vitro dissolution evaluations.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran