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Development and validation of rp-hplc method for simultaneous estimation of metformin and evoglitpin in dosage form

Author: 
Rupali Bagde, S Karole, Anup K Chakraborty and Kavita R Loksh
Subject Area: 
Life Sciences
Abstract: 

A new RP-HPLC method was developed and validated for the simultaneous estimation of metformin and evogliptin in dosage form. The chromatogram of the mixed standard was found to be satisfactory on C-18 (4.6×150mm, 5µ Hypersil column) using isocratic mixture of methanol 700 ml and 300 ml water (pH adjusted to 3.0 with orthophosphoric acid) at a flow rate of 0.8 ml/min and detection wavelength of 254 nm. The retention time of metformin and evogliptin were found to be 2.548 min and 2.107 min respectively. The system suitability parameters justify that the proposed method is suitable for simultaneous estimation of metformin and evogliptin with the theoretical plates for separation being 5633 and 4154 respectively. The method was found to be linear in the range of 10-50µg/ml for metformin and 1 to 5µg/ml for evogliption. The precision of the method was good and the recovery of drugs is well within the acceptance limits of 80-120%. The LOD was found to be 0.058 µg/ml for metformin and 0.015 µg/ml for evogliptin while the LOQ ws found to be 0.178 µg/ml for metformin and 0.047 µg/ml for evogliptin.

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