Parents expect a safe learning environment for their children while in teachers’ custody, yet threats to student safety are increasing globally, and Kenya is no exception. In Kisumu County, incidents of floods, criminal activity, community conflicts, fires and strikes continue to be recorded in schools. Due to legal responsibility and their position as first responders in school emergency, teachers have a crucial role in ensuring student safety, yet little has been done to explore teacher knowledge on management of student safety in emergency incidents in public secondary schools. The purpose of this study was to determine contribution of teacher knowledge on management of student safety in emergency incidents in public secondary schools in Kisumu County. The objective of the study was to examine the contribution of teacher knowledge to management of student safety in emergency incidents in public secondary schools in Kisumu County. The study established that; teacher knowledge and practices moderately contributed to student safety with overall mean ratings of 3.22 and 2.96 respectively. Findings of this study are important to educational administrators, policy makers and planners in understanding how teacher knowledge in emergency incidents contribute to student safety in emergency incidents in public secondary schools.