Ayurveda described about Acute and Chronic toxicity but also about unique concept of Dushivisha and Garavisha. Now-a-days the incidence and prevalence of diabetes in non-communicable disease increasing as flame of forest. Today we Indians looking towards western world and adopting their culture as well as population explosion, industrialization further added harmful chemicals to our environment and food materials. Such chemicals or toxic substance remains inside for long duration as cumulative effect produces diseases such diabetes, Thyroid disorders, skin diseases, respiratory disorders etc. due to its Dushivisha (cumulative) effect. Hence, the Dushivisha concept is still applicable for diabetes in present era.