Comparison of ejection fraction values calculated by tc-99m mibi gated spect, f-18 fdg cardiac gated pet, muga spect and echocardiography methods in viability patients

Objective: In our study, we aimed to investigate the correlation between left ventricular ejection fraction (LVEF) values measured by four modalities. Materials and methods: Among the patients who underwent myocardial perfusion scintigraphy for ischemia/infarct detection and cardiac PET for cardiac viability evaluation, MUGA imaging was performed in patients who agreed to participate in our study. 12 patients, 10 males (83.3%) and 2 females (16.7%), were included in the study (age: 64.66±9.76 (51-81)). LVEF values were measured in all 3 methods. In addition, LVEF values obtained by ECHO performed in the cardiology clinic were also obtained from the patient file.A value of p<0.05 was considered statistically significant. Results: LVEF calculated by MUGA SPECT method was found to be statistically significantly higher than LVEF calculated by Tc-99m MIBI GATED SPECT and F-18 FDG cardiac GATED PET (p=0.01; p=0.01). In the Spearman's correlation test, the LVEF value measured in MUGA SPECT showed a positive high correlation with the LVEF values measured in Tc-99m MIBI GATED SPECT and F-18 FDG cardiac GATED PET (p=0.01, r=0.80; p=0.01, r=0.95).A moderate positive correlation was detected between the LVEF value measured in MUGA SPECT and the LVEF value measured in ECHO (p=0.03, r=0.62). Conclusion: Each of the four methods was able to measure LVEF in correlation with each other. LVEF values measured by Tc-99m MIBI GATED SPECT and F-18 FDG GATED cardiac PET showed a high positive correlation with MUGA SPECT. It can be inferred that these examinations can be used interchangeably for LVEF measurement.