A comparative study on the antimicrobial activity of antibiotics and antibiotic and probiotic combinations against klebsiella pneumoniae

Probotics are microorganisms which has a potential to put positive health effect upon the health of human and animals. Their antagonistic potential is being utilized to overcome the increasing drug resistance of common pathogens. Present study is an attempt to further evaluate their antagonistic potential against resistance pathogen Klebsiella Pneumoniae. For this the synergistic antagonistic activity of probiotics and antibiotic combinations was carried out by using Kirby Bauer disc diffusion method. Out of the total tests in 68.75% cases probiotics were found to enhance the antagonistic activity of antibiotics while in 31.25% antimicrobial activity of antibiotics remained the same. None of the probotic strain caused reduction in the antimicrobial activity of the antibiotics in combination. Probiotics must be tried as an agent to overcome the leading drug resistance of the pathogens.