The crop combination regionalization is a method to examine the cropping pattern of an area. In this process, the existing cropping pattern is analysed and the best combination of crops is proposed for the highest productivity in that area. The combination of crops in an area is influenced by numerous physical and human factors. This study has been carried out on Kheri district, Uttar Pradesh, India. Secondary data has been used gathered from the District Statistical Magazines. The ranking of specific crops is estimated by percentage method. Doi’s method has been applied to examine the crop combinations in the different blocks. A comparative analysis of two different agricultural years was presented. The findings show that Sugarcane is the main crop in the district and occupying as the first rank in most of the blocks. However, wheat and rice are other crops occupying second and third positions in different blocks. Oilseed, pulses, maize, fodder, and vegetables are other minor crops of the district. According to Doi’s technique, most of the blocks are experiencing three crop combinations, only one block having monoculture and two blocks featuring two crop combinations in 2016-17. Moreover, in the year 2006-07, all the blocks experiencing three crop combinations in the district.