CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Comparative analysis between the protein mcp-1 and neurotrophins involved in alopecia areata

Author: 
Shrasti Gupta, Vijay Laxmi Saxena and Vertika Saxena
Subject Area: 
Life Sciences
Abstract: 

Alopecia Areata is an autoimmune disease. It is an unpredictable disorder which can occur to a person of any age, it is commonly found in children and it also occurs in animals besides human beings. The two proteins are found to be involved in Alopecia Areata i.e. PDB ID 1SG1 of Neurotrophins family and PDB ID 1DOK of MCP-1 protein. Neurotrophins are the group of proteins, experimental data suggests that they may regulate cyclic activity of hair follicle and MCP-1 proteins are found to be present around the area having Alopecia Areata, as known from literature it increase the rate of hair follicle shedding by promoting more T-lymphocytes towards the point of growth of hair follicle and a comparison is being done between the two PDB ID 1SG1 of Neurotrophins family and 1DOK of protein MCP-1, along with the comparison between the various zinc analogs on basis of 99%, 95%, 90% similarity, for best docking results with both the protein’s PDB ID’s, for predicting a zinc analog which can be identified under the category of becoming a potential drug candidate in future. The best moldock scores were for zinc analog ZINC ID 22052012 for Biotin is -183.662 Kcal/mol, ZINC ID 13475552 for Capsaicin is -190.116 Kcal/mol and ZINC ID 09222049 for Epicatechin-3-gallate is -196.679 Kcal/mol. The two parameters for toxicity properties i.e. Oral rat LD50 and Mutagenicity were calculated, the Oral rat LD50 values for Biotin, Capsaicin and Epicatechin-3-gallate were 895.76, 3864.96 and 2178.79 mg/kg and the Mutagenicity values for Biotin, Capsaicin and Epicatechin-3-gallate were 0.17, 0.19 and 0.77 respectively. Thus finally the selected Zinc Analogs ZINC ID 22052012, ZINC ID 13475552, ZINC ID 09222049 is for three of the natural ligands i.e. Biotin, Capsaicin, Epicatechin-3-gallate respectively.

PDF file: 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran