Carcinoma of the gall bladder: a retrospective study in a tertiary care hospital of Delhi with Ihc profile

Background: Gall Bladder Cancer (GBC) is a malignancy of aggressive nature with ethnic and geographical patterns. It is most commonly reported from Chile (16-27/100,000), Japan. In India, its incidence is from 1.01 per 100000 to 10.1 per 100000 in males & females respectively. Aim and Objectives: The objectives of the study were to analyze the demographics, incidence, histopathological findings with immunoprofiling in gall bladder carcinomas. Material and Methods: A retrospective analysis of 1208 cholecystectomy specimens were received for histopathology from 2011 till 2015 in a tertiary care hospital Delhiand analyzed. Results: A total number of 45 cases of carcinoma of gall bladder were diagnosed which included 43cases of Adenocarcinoma, 2 cases of Adenosquamous carcinoma. Most gall bladder adenocarcinomas were of pancreatobiliary-type, showing variable degrees of differentiation. Female: male ratio of 3.6: 1was observed, with mean age being 51years. Conclusions: Gall bladder carcinoma is rare, constituting 3-5% of all the gastrointestinal tumours. Gall stones are considered as one of the most common factors for initiating the malignant process. The patients are in advanced stages at initial presentation. Early diagnosis is difficult usually as they are common with benign disease of gall bladder. Further, correlation with radiographic and clinical findings is also important to avoid misdiagnosis.