Behcet’s disease: a histopathological perspective

Behcet’s disease is an uncommon systemic vasculitis disorder of idiopathic nature. Almost all aspects of the disease are controversial including its diagnostic criteria, classification and pathogenesis. Patients present with frequent oral aphthous ulcers, genital ulcers, skin lesions and ocular lesions. Usually the inflammation is self limiting but relapsing episodes are hallmark of the disease. It also involves the central nervous system, large vessels and gastrointestinal tract. Histopathological and immunohistochemical examination plays an important role in the diagnostic accuracy of these lesions. New treatment modalities aims to target towards cytokines such as TNF-α, IFN-γ, IL-β, IL-6 and IL-8. Prognosis is unfavourable despite various therapeutic advancements. We herein present a case in a 21 year old male with recurrent oral and genital ulcers.