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Allelic variation of p53 codon 72 “exon4” in colorectal cancer in sudanese patients

Author:

Mohamed El-Fatih Mohy El-Deen, Esam Mohamed Abdul Raheem and Ashwag Mohamed Mokhtar

Subject Area:

Health Sciences

Abstract:

Study Design and Objective: This was a prospective case control hospital based study aimed to identify the allelic variation of p53 codon 72 “exon 4” in colorectal cancer lesions in Sudanese patients. Material and Methods: Endoscopic biopsies were obtained from 82 Sudanese patients with colorectal mucosal changes, DNA was extracted, and genotyping was performed using Allele Specific PCR (AS-PCR) to detect proline and arginine alleles. Results: In the cancer-free group specimens, the genotype distribution for p53 polymorphism showed 8.6 %, 60 %, and 31.4 % for the Arg/Arg, Arg/Pro, and Pro/Pro genotypes, respectively. In the colorectal cancer group specimens, 12.8 % were Arg/Arg, 51 % were Arg/Pro, and 36.2 % of the cases were Pro/Pro. Conclusion: Proline Homozygosity may be correlated with possible increased risk of colorectal cancer in Sudan.

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