Pathology is a branch of medical science that help in diagnosing the disease by microscopic examination and revealing the information to render correct diagnosis and help in proper treatment planning. Recent advances in technology has put a significant impact in the diagnostic field of pathology. Introduction of slide less pathology also known as Virtual Microscopy or Whole slide imaging (WSI) is not mere an imagination but an upcoming and promising invention. It is highly demanded in everyday pathology as well as in educational, research purpose and bioindustry. Even though these advances are faced with significant challenges such as data storage, image compression, they also provide guidance to newer diagnostic approach. These can also minimize the interobserver variability, diagnostic dilemma, identifies the therapeutic pathways and predicts the patient responses to therapy. Hence the promise of digital pathology is not the simple transfer of an image to monitor, but rather an upgradation with information that cannot be garnered by human examination. This article aims to introduce and discuss the important aspects of this evolving technology.