Polyphenols excretion reduces lipids peroxidation, hyperuricemia and hypercholesterolemia in type-2 tunisian diabetics

Epidemiologic studies suggest that tea-polyphenols consumption may be beneficial in the prevention and control of type-2 diabetes. The objective of this work was to examine the effect of the absorbed polyphenols, assessed through their plasma and urinary concentrations, on the total antioxidant status, lipids peroxidation and other metabolic parameters in type -2 Tunisian diabetics. A sample of 244 type-2 diabetic patients was enrolled in this study. Green tea consumption, assessed as tea cups/ day was recorded. The malondihaldehyde, as early marker of lipid peroxidation, total antioxidant status, plasma and urinary polyphenols levels and other metabolic parameters were determined by appropriate methods. Uric acid and malondihaldehyde levels were significantly reduced in higher consumers of tea (>3 cups/day) compared to moderate consumers (<3 cups/day) (P=0.02 and P<0.001; respectively). Moreover, the urinary polyphenols was inversely correlated with total cholesterol, LDL-cholesterol andtotal antioxidant status (P=0.011, P=0.008, P =0.028; respectively). These results suggest that the final flavonols metabolites found in urine may be responsible of the hypocholesterolemic; hypouricemic and the reducing of lipid peroxidation observed in type -2 diabetics.