Background/Introduction: Irrigation of root canal system is one of the most important steps in endodontic treatment. Combining different irrigants may modify the efficiency of the irrigation in removing organic and inorganic debris during biomechanical pr

Oral submucous fibrosis (OSMF) is a potentially malignant collagen metabolic disorder affecting the oral cavity due to the imbalance in collagen production and breakdown mediated by transforming growth factor beta (TGF-β). Numerous modalities ranging from behavioural therapy, physiotherapy, steroids, enzymes, nutritional supplements, antioxidants, interferons, turmeric, ayurveda to various drugs have been tried with weak evidence requiring better documentation of the studies performed with standardized criteria. One drug perfinidone (5-methyl-1-phenyl-2-(1H) pyridine) a novel antifibrotic agent used extensively in lung, cardiac and liver fibrosis has still not been tried in OSMF. This drug mainly exerts it action blocking the action of TGF-β. A positive outcome with prolonged research and numerous clinical trials, evaluating the systemic and topical uses of pirfenidone in OSMF with can give a ray of hope to these patients, helping them achieve a better quality of life. This paper aims at proposing this drug in the treatment of OSMF which can be beneficial in managing this progressively debilitating disease, significantly improving quality of life.