Use of platelet rich plasma (PRP) with hydroxyapatite in post surgical jaw defects

Objective: To evaluate the effect of Platelet-rich plasma (PRP) with hydroxyapatite (HA) in healing of post surgical osseous defects clinically and radio graphically. To evaluate the role of PRP in modifying the physiologic response to grafting of alveolar bone defects in maxillofacial region. Methods: After selection according to inclusion and exclusion criterias, 40 patients were selected. All the patients were to undergo surgical enucleation of the cystic lesion or extraction of impacted mandibular teeth, followed by placement of platelet rich plasma (PRP) with hydroxyapatite in the surgical defect. Pre operative and post operative radiographs, ultrasonography and colordoppler were utilized as diagnostic tools. Surgery was performed. After removal of the lesion/tooth the bone defect was packed with mixture of platelet rich plasma (PRP) and hydroxyappatite (HA). Closure of wound was achieved by interrupted sutures using 000 black silk with 16 mm 3/8 reverse cutting needle. The data was analyzed statistically. Results: the findings of the study suggest that platelet rich plasma is a feasible method to treat post-treatment jaw defects with a very high success rate and very low rate of complications such as pain, swelling and infection. Ultrasonographic evaluation proved to be very beneficial in evaluation of bone formation and calcification whereas Color Doppler evaluation helped to predict the vascularization of the affected area thus showing the evidence of wound healing.