Tissue engineering is an interdisciplinary field that applies principles and methods of engineering and the life sciences towards the development of biological substitutes that restore, maintain, and improve the function of damaged tissues and organs. The goal of tissue engineering is to promote healing, and ideally, true regeneration of a tissue’s structure and function, more predictably, more quickly, less invasively, and more qualitatively than allowed by previous passive techniques. The aim of this article is to bring awareness among the dentists about the huge potential associated with the use of stem cells in a clinical setting, as well as the growth factors promote true regeneration of the periodontal attachment apparatus and the use of combination protein therapeutics which is commercially available can provide more predictable, faster, less invasive, less traumatic, and efficient outcome for the patient.