Synergistic antidiabetic activity of liquorice and jatamansi in alloxan induced diabetic rats

Diabetes mellitus is a metabolic disorder that is rapidly becoming a major threat to population all over the globe. Diabetes is due to either the pancreas not producing enough insulin or because cells of the body do not respond properly to the insulin that is produced. Antidiabetics from natural source play a key role in treatment of diabetes. Herbal plants are power house of sources for anti-diabetic principles. The present study aimed the anti-diabetic activity of combined extract of liquorice and jatamansi. Liquorice previously proven for anti-diabetic activity. But in this study carried Synergistic ant diabetic actions of combination extract liquorise and jatamansi in Alloxan induced diabetic rats. The overnight fasted non diabetic rats are treated with alloxan monohydrate 50mg|kg body weight among them rats with plasma glucose level >150mg|dl were selected for diabetic study. The liquorice & jatamansi extract which is prepared in solvent ether is administered for test group along with glibenclamide for standard group which is sulfonyl urea’s for about 7days. Test sample showed significant decrease in blood glucose level of diabetic rats at the dose 200mg|kg body wt. compared to diabetic controlled rats. Glibenclamide also showed decrease in blood glucose level at the dose 5mg/kg body wt. Hence our present study revealed the synergistic action of liquorice & jatamansi near to the standard and minimal side effects and less cost with easy available of drugs