Introduction: Medications are an amazing discovery. They promote healing, reduce suffering and contribute to modern medical miracles. However, because thousand of new drugs have been developed recently because the health care environment is increasingly complex and because the patients are often sicker, there is increasing risk for medication errors (Shivayogi, 2014). Medication error are one of the serious problem in health care and can be source of significant morbidity and mortality in the health care setting medication error is recognized as the eight leading cause of death, but it can be prevented with strategies like safe administration of oral medication (Rekha, 2013). Aim of the study: To assess parental ability regarding safe administration of oral medication in children after implementation of Educational Package (EP). Methods and materials: This Quasi-experimental study using one group post test only research design was conducted at Civil Hospital, Panchkula, Haryana, India, using non probability purposive sample size 100 parents was used to collect the data regarding the safe administration of oral medication. 9 demographic variables of parents and 4 clinical variables of children were use to collect personal data. Observational checklists were used for the data collection with maximum score was 22 and the minimum score was 0 and analyzed with descriptive and inferential statistics. Educational Package (EP) was given to them in form of demonstration regarding safe administration of oral medication in children. After 3 (three) days post test was done to evaluate the effectiveness of Educational Package (EP) in terms of parental ability regarding safe administration of oral medication in children through observation checklist. Results: Out of 100 parents, majority of parents had excellent (59%) parental ability regarding safe administration of oral medication after implementation of Educational Package (EP). Qualification (0.376), health profession (0.515) and previous knowledge (0.557) were found to be associated at 0.05 level of significance. Conclusion: Based on the findings of the study, it is concluded that majority of parents had excellent (59%) level of parental ability regarding safe administration of oral medication in children. Educational Package (EP) help the parents to enhance their parental ability regarding safe administration of oral medication evidenced by the post test score. Educational Package (EP) must be demonstrating to the parents in order to improve parental ability regarding safe administration of oral medication in children.