Study of different phenotypes in polycystic ovarian syndrome and their correlation with AMH

Objectives: To study different phenotypes in PCOS and their correlation with AMH Methods: This prospective case-control study included 90 patients attending Gynaecology out patient Department of Dr RML Hospital, New Delhi from 1st November 2015 to 31st March 2017. Clinical history and examination including Ferriman Gallwey scoring, BMI, investigations including pelvic ultrasonography and blood serum FSH, LH, estradiol, TSH, prolactin, testosterone (total) and AMH was done for all the women. The patients were divided into two equal study groups of 45 each – PCOS diagnosed using Rotterdam criteria and Controls, using inclusion and exclusion criteria. Results: The mean age and BMI of cases and control were similar with no statistical difference. Mean FG score of 10.13 in PCOS case was statistically higher than in control. Mean AMH levels of 6.08ng/ml in cases was almost twice that of 2.98 ng/ml in control (p<0.0001). In PCOS, positive correlation of AMH to FG score and negative correlation with oligomenorrhea was observed. Phenotype A (HA+OA+PCOM) was most prevalent (42.22%) with highest AMH level of 7.96 ng/ml. Prevalence of phenotype D (OA+PCOM), phenotype B (OA+HA) and phenotype C (HA+PCOM) were 28.88%, 15.55%, and 13.33% respectively. Conclusion: AMH levels were significantly higher in PCOS than control. Phenotype A was the commonest, with highest AMH levels. AMH had a positive correlation to FG score and negative correlation with oligomenorrhea.