Cardio vascular disease such as angina pectoris and ischemic disease is a major disorder in India.Treatment of angina pectoris is traditionally aimed at reduction of symptoms as well as prevention of future cardiac events such as myocardial infarction or death. 15% of refractory angina pectoris patients either fail to respond fully to such therapy or ineligible to further intervention. External Counter Pulsation therapy (ECP) is a non pharmacologic, cost effective and non invasive therapy can be use safely in any age group without any complication. Education is one of the best way to change knowledge and attitude of staff nurses working in hospital. This has motivated the researcher to conduct a study “A study to assess effectiveness of structured teaching programme on external counter pulsation therapy among staff nurses working in selected hospitals at Bangalore”. Objective of the study: To evaluate the effectiveness of structured teaching programme on external counter pulsation therapy by comparing pre and post test knowledge score among staff nurses. Methodology: One group pre-test, post-test research design, which is a pre experimental design with purposive sampling method, is used to select 40 staff nurse. The study was conducted in Pristine Cardiac hospital, Bangalore. The tool used for the data collection was self administered structured knowledge questionnaire which comprised of 8 items on demographic data and 40 items on knowledge of External counter pulsation therapy. The reliability of the tool was established by using Test-Retest method. The reliability Co-efficient is 0.965. The pre test was administered to 40 staff nurses followed by the STP then post test was conducted after 7 days to the same samples using the same tool. The conceptual framework used for this study is based on Stufflebean “CIPP evaluation model”. Data gathered was analyzed using descriptive and inferential statistics in terms of frequency, percentage, mean, standard deviation, paired‘t’ test and chi-square test. Results: The present study conducted to assess the effectiveness of STP on ECP therapy among staff nurses highlights that the pre-test mean knowledge scores was 28.22% while post-test mean knowledge scores was 74.44%. Further the statistical obtained‘t’ value was 25.61, which is significant at 5% level. There exists a significant difference between pre-test and post-test knowledge scores among participants. Hence H1 is accepted. The findings revealed that there is significant association between pre-test knowledge scores of staff nurses on ECP therapy with demographic variables such as professional experience and family income. Hence H2 is accepted .But there is no significant association between pre-test knowledge scores of ECP therapy with demographic variables such as age group, gender, professional qualification, and duration of experience as a cardiac nurse, professional experience and source of information. Hence H2 is rejected and null hypothesis is accepted. Conclusion: Hence the findings revealed that structured teaching programme was effective in enhancement of the knowledge of staff nurses on External Counter Pulsation Therapy. The study recommends nurses can use this knowledge for caring patients with ECP therapy.