Endometrial cancer (EC) has an increasing incidence worldwide. Lymph node status is a strong predictive factor of recurrence. Therefore, determination of the nodal status is very important in order to optimally tailor adjuvant therapies and to reduce local and distant recurrences. Imaging modalities do not yet provide accurate lymph node staging, thus pelvic and aortic lymphadenectomies remain standard staging procedures. Sentinel lymph node (SLN) biopsy is intended to avoid extensive lymphadenectomy with its related morbidity and to provide significant oncologic information. This technique is emerging as a new standard for EC staging procedures.