Aim: The purpose of this study was to compare the sealing ability of Endosequence Root Repair Material (ERRM), Mineral Trioxide Aggregate (MTA) and Ketac Molar easy mix GIC when used as furcal perforation repair materials. Methodology: A total of 105 human mandibular molars were used. Root canal treatment was carried out following which standardized furcal perforations were made. The specimen were randomly divided into three groups of 25 teeth each. In groups A, B, and C furcation perforations were filled with ERRM, MTA and GIC respectively. Fifteen teeth were used as the positive controlwith no filling materialin the perforationand fifteen teeth were used as negative control with complete closure of the perforation with two layers of nail varnish. A protein leakage model utilizing 22% bovine serum albumin (BSA) was used for evaluation. Leakage was noted when color conversion of the protein reagent was observed. Leakage was found in all the samples from Group A (ERRM), Group B (MTA), and Group C (GIC). Result: There was no statistically significant difference between ERRM and MTA, however, there was a statistically significant difference in GIC as compared to ERRM and MTA. Conclusion: Microleakage with ERRM is equivalent to MTA therefore ERRM is a good alternative to MTA for furcal perforation repair.