Introduction: leprosy is the most common treatable peripheral nerve disorder. As high resolution sonography provides objective measurements of nerve thickening, we used it to demonstrate nerve enlargement in leprosy patients. Aim and objectives: The aim of the study was to assess the usefulness of high resolution sonography in assessing nerve damage in leprosy patients Materials and methods: We performed bilateral high resolution sonography of ulnar, median and common fibular nerves in 20 leprosy patients and 20 healthy controls. Results: The nerves were significantly thicker in the leprosy patients as compared to healthy controls (p<0.0001 for each nerve) Conclusion: High resolution USG is useful in early diagnosis of leprosy neuropathy.