Background: These diseases are considered as professional diseases. Severity of technological disease usually responds to the level and duration of exposure, and usually occurs after many years of exposure to harmful factor. Diseases occur due to excessive work at the computer, or excessive use of keyboards and computer mouse, especially the non-ergonomic ones. Objective: This randomized controlled study was conducted to compare the effectiveness on pain and upper limb function of mirror therapy and ergonomics in mouse shoulder. Methods: Of 30 patients which include 15 for control group who was received stretching and strengthening for 40 min. and 15 for experimental group who was received stretching, strengthening with mirror therapy program and ergonomics for 40 min. and advised them vertical mouse. The primary end points were a reduction in the shoulder pain disability index scale score of pain. The secondary end points were improvement in motor function and Posture. Results: The mean scores of both the primary and secondary end points significantly improved in the mirror group. No statistically significant improvement was observed in any of the control group values posture and shoulder pain and disability index (p= 0.188 and p= 0.1038) but experimental group has shown essential significant result in posture and shoulder pain and disability index (p= 0.0001 and p= <0.0001) Moreover, statistically significant differences after treatment (P < .0001) and at the 4 weeks follow-up were found between the 2 groups. Conclusions: The results indicate that mirror therapy and ergonomics are effectively reduces pain.